Automated, Closed loop, In-Line monitoring of CAR-T cells in a production process
OVIZIO has developed an in-line, automated microscope that generates reliable viable cell counts without the need for active sampling, in real time and without any labelling. Its versatility makes it compatible with off-the-shelf stirred tanks, rocking motion bags and various other cell culture vessels.
The cell characterization and quantification are based on OVIZIO’s patented technology: Double Differential Digital Holographic Microscopy (D3HM). The microscope generates a holographic fingerprint based on 70 characteristics for every cell that is imaged and feeds to a machine learning platform. Fast and accurate, the algorithms automatically discriminate between different cellular status and give access to in-depth quality attributes and dynamic properties of your cell culture, and may also provide additional information on a single cell level.